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Related Experiment Videos

Tissue factor as a proinflammatory agent.

Maria I Bokarewa1, James H Morrissey, Andrej Tarkowski

  • 1Department of Rheumatology, Sahlgrenska Hospital, Göteborg, Sweden. maria.bokarewa@rheuma.gu.se

Arthritis Research
|May 16, 2002
PubMed
Summary
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Tissue factor (TF) triggers blood coagulation and inflammation. This study found TF induces arthritis primarily through monocytes and chemokines, highlighting its dual role in immune and coagulation systems.

Area of Science:

  • Immunology
  • Hematology
  • Rheumatology

Background:

  • Tissue factor (TF) is a key initiator of blood coagulation.
  • TF expression is typically induced by inflammatory signals on monocytes and endothelial cells.
  • Its own proinflammatory capacity has not been fully elucidated.

Purpose of the Study:

  • To investigate the intrinsic proinflammatory capacity of Tissue Factor (TF).
  • To determine the role of immune cells, particularly monocytes and lymphocytes, in TF-induced arthritis.
  • To explore the mechanisms by which TF mediates inflammation.

Main Methods:

  • Intra-articular injection of recombinant extracellular TF domain into healthy mice.
  • Utilized immune cell-depleted mice (lymphocytes, neutrophils, monocytes).

Related Experiment Videos

  • Histomorphological analysis of joint tissues and assessment of chemokine production.

    • Main Results:

    • Intra-articular TF induced arthritis in 80% of mice, characterized by synovial proliferation, pannus formation, and cartilage destruction.
    • Inflammatory infiltrate primarily comprised CD4-Mac1+ macrophages.
    • Combined depletion of monocytes and lymphocytes was necessary to prevent TF-induced inflammation.
    • TF induced chemokine (MIP-1alpha, RANTES) production but not direct T-cell activation.

    Conclusions:

    • Tissue Factor possesses significant inflammatogenic properties.
    • TF-induced arthritis is predominantly mediated by monocytes and their chemokine release.
    • TF acts as a simultaneous trigger for both the immune and coagulation systems.