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New developments in childhood celiac disease
Carlo Catassi1, Alessio Fasano
1Center for Celiac Research, Division of Pediatric Gastroenterology and Nutrition, University of Maryland School of Medicine, 685 West Baltimore Street, HSF Building, Room 465, Baltimore, MD 21201, USA.
Insights
Celiac disease (CD) is a common lifelong disorder in children and adults, triggered by gluten in susceptible individuals. This review highlights new pediatric CD developments and stresses healthcare professional awareness.
Area of Science:
- Gastroenterology
- Pediatric Medicine
- Immunology
Background:
- Celiac disease (CD) is a prevalent, lifelong, immune-mediated disorder affecting genetically susceptible individuals.
- It is characterized by an enteropathy triggered by gluten ingestion.
- CD affects both pediatric and adult populations in Europe and the United States.
Purpose of the Study:
- To review recent advancements in celiac disease specifically concerning pediatric patients.
- To underscore the importance of heightened awareness among healthcare professionals regarding pediatric CD.
- To provide a comprehensive overview of pediatric CD.
Main Methods:
- Literature review focusing on recent developments in pediatric celiac disease.
- Synthesis of information on epidemiology, pathophysiology, diagnosis, and clinical presentation.
- Emphasis on clinical aspects relevant to healthcare providers.
Main Results:
- Celiac disease is a significant health concern in children, with ongoing research into its various facets.
- Understanding the epidemiology and pathophysiology is crucial for early detection and management.
- The clinical spectrum of CD in children necessitates a high index of suspicion for diagnosis.
Conclusions:
- Increased awareness and updated knowledge are vital for effective management of celiac disease in children.
- Early diagnosis and appropriate care are essential for improving outcomes in pediatric patients.
- Continued research is needed to further elucidate and address challenges in pediatric celiac disease.
Abstract:
Celiac disease (CD) is one of the most common lifelong disorders in Europe and the United States, in both children and adults. It is an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. This review addresses new developments in CD with respect to pediatric patients and emphasizes the need for awareness among health-care professionals. The epidemiology, pathophysiology, diagnosis, and clinical spectrum of CD in children are highlighted.