Related Experiment Video
Updated: Jul 5, 2026

Seven Steps to Stellate Cells
Published on: May 10, 2011
Transcriptional regulation of hepatic stellate cell activation
1Liver Group, Division of Infection, Inflammation, and Repair, University of Southampton, Southampton, UK. dam2@soton.ac.uk
Abstract:
The hepatic stellate cell (HSC) is now well established as the key cellular element involved in the development of hepatic fibrosis and because of this there is considerable interest in establishing the molecular events that trigger and perpetuate HSC activation. HSC activation at the level of gene transcription requires the coordinated activity of several key transcriptional regulators of the HSC genome. The considerable advances that have been made in the past five years into the mechanisms by which specific families of transcription factors regulate the profibrogenic characteristics of the activated HSC are reviewed.
Related Concept Videos
Cell Specific Gene Expression
Co-activators and Co-repressors
Master Transcription Regulators
General Transcription Factors
Liver Regeneration
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
Cirrhosis II: Pathophysiology

