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Updated: Aug 18, 2026

A Genetic Screen to Isolate Toxoplasma gondii Host-cell Egress Mutants
Published on: February 8, 2012
Secretory traffic in the eukaryotic parasite Toxoplasma gondii: less is more
1Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06520, USA. keith.joyner@yale.edu
Abstract:
Name a single-celled eukaryote that boasts a small genome size, is easily cultivated in haploid form, for which a wide variety of molecular genetic tools are available, and that exhibits a simple, polarized secretory apparatus with a well-defined endoplasmic reticulum and Golgi that can serve as a model for understanding secretion. Got it? Now name a cell with all these attributes that contains at least a dozen distinct and morphologically well-defined intracellular organelles, including three distinct types of secretory vesicles and two endosymbiotic organelles. Not so sure anymore?
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