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Diabetes and postcataract extraction endophthalmitis.

Bernard H Doft¹, Stephen R Wisniewski, Sheryl F Kelsey

¹Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA. doft@pitt.edu

Current Opinion in Ophthalmology

|May 16, 2002

Summary

Diabetic patients with endophthalmitis had worse outcomes and vision. Vitrectomy showed benefits for diabetics with light perception vision, but further research is needed for other cases.

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Area of Science:

Ophthalmology
Diabetic Retinopathy
Infectious Eye Disease

Background:

Endophthalmitis is a serious eye infection.
Diabetes may influence endophthalmitis presentation and treatment response.

Purpose of the Study:

To explore treatment response differences in diabetic versus nondiabetic patients with endophthalmitis.
To investigate if endophthalmitis signs and symptoms differ between diabetic and nondiabetic individuals.

Main Methods:

Exploratory analysis of patients from the Endophthalmitis Vitrectomy Study.
Random assignment to vitrectomy or tap/biopsy treatment.
9-month follow-up with visual acuity assessment.

Main Results:

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Diabetic patients (58/420) presented with worse vision and ocular media.

39% of diabetics achieved 20/40 final vision versus 55% of nondiabetics.

Vitrectomy improved outcomes for diabetics with light perception vision.

Conclusions:

Diabetic status may impact endophthalmitis outcomes.
Vitrectomy appears more beneficial for diabetics with initial light perception vision.
Further clinical trials are required to confirm treatment differences in diabetic patients with better than light perception vision.