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Topically applied aspirin decreases histamine-induced wheal and flare reactions in normal and SLS-inflamed skin, but
J S Thomsen1, E Benfeldt, S B Jensen
1Department of Dermatology, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark. jeth@gentoftehosp.kbhamt.dk
Acta Dermato-Venereologica
|May 16, 2002
Summary
Topical aspirin did not reduce itch from histamine injections in a skin inflammation model. While it penetrated the skin, affecting wheal and flare reactions, it did not provide antipruritic effects in this study.
Area of Science:
- Dermatology
- Pharmacology
- Pruritus Research
Background:
- Recent reports suggest topical aspirin may reduce histamine-induced itch.
- The antipruritic efficacy of topical aspirin, particularly in inflamed skin, requires further investigation.
Purpose of the Study:
- To confirm the antipruritic effect of topical aspirin on histamine-induced itch.
- To evaluate the efficacy of topical aspirin in inflamed skin models.
Main Methods:
- Twenty-four volunteers underwent induced skin inflammation using sodium lauryl sulphate.
- Aspirin (10%, 1%) and mepyramine (5%) were applied topically before histamine injection.
- Itch, pain, wheal, and flare responses were measured using visual analogue scales and area measurements.
Main Results:
- Topical aspirin did not significantly decrease histamine-induced itch in normal or inflamed skin.
- Aspirin and mepyramine showed significant skin penetration, reducing flare and wheal areas in both normal and inflamed skin.
- Inflamed skin pretreated with aspirin or mepyramine experienced more itch compared to normal skin.
Conclusions:
- Topical aspirin does not alleviate histamine-induced itch in the experimental model used.
- Despite demonstrating skin penetration and anti-inflammatory effects on wheal and flare, aspirin lacks antipruritic properties in this context.