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Related Experiment Videos

Intravenous tranquillization with ECT.

J Gomez, P Dally

    The British Journal of Psychiatry : the Journal of Mental Science
    |December 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Electro-convulsive therapy (ECT) can cause agitation and side effects, especially in anxious patients. Tranquilizers like diazepam and haloperidol can reduce these adverse effects during ECT treatment.

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    Area of Science:

    • Psychiatry
    • Neuroscience
    • Pharmacology

    Background:

    • Electro-convulsive therapy (ECT) is a treatment for severe depression.
    • Anxiety can exacerbate side effects of ECT, including agitation and memory impairment.
    • The use of pre-treatment medication to mitigate ECT side effects is an area of clinical interest.

    Purpose of the Study:

    • To investigate the efficacy of pre-anesthetic intravenous diazepam and haloperidol in reducing post-treatment agitation and side effects in depressed patients undergoing ECT.
    • To determine if pre-treatment anxiety levels influence the occurrence and severity of ECT-associated adverse events.

    Main Methods:

    • Forty in-patients diagnosed with depression and prescribed ECT were assessed.
    • Patients were rated on depression and anxiety scales prior to treatment.

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  • Side effects, post-operative agitation, and retrograde memory impairment were evaluated after each ECT session.
  • Comparisons were made between ECT administered without medication and with intravenous diazepam or haloperidol given before anesthesia.

    • Main Results:

    • High pre-treatment anxiety significantly correlated with increased post-operative agitation and side effects when ECT was given without tranquilizers.
    • Both diazepam and haloperidol effectively reduced agitation and side effects in anxious, depressed patients.
    • Patients receiving diazepam experienced a longer recovery time compared to those receiving haloperidol.

    Conclusions:

    • Pre-treatment anxiety is a critical factor influencing ECT side effect severity.
    • Intravenous diazepam and haloperidol are effective in managing agitation and side effects associated with ECT in anxious, depressed patients.
    • While both medications are beneficial, haloperidol may offer a quicker recovery profile than diazepam.