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Updated: Oct 1, 2026
miRNA Expression Analyses in Prostate Cancer Clinical Tissues
Published on: September 8, 2015
Androgen receptor (AR) expression in normal and cancerous human endometrial tissues detected by RT-PCR and
Magdalena Brys1, Andrzej Semczuk, Wlodzimierz Baranowski
1Department of Cytobiochemistry, University of Lodź, Poland.
Objective:
This study aimed at assessing the expression and cellular localisation of the androgen receptor (AR) in normal and malignant human endometrial tissues.
Materials And Methods:
Twelve normal endometrial samples and 25 uterine cancers were studied using RT-PCR and immunohistochemistry (IHC).
Results:
One of the 12 (8%) normal endometrial samples showed AR PCR-product, whereas 4 of the 25 (16%) cancers displayed AR expression. Tumor tissues and normal tissues did not differ significantly in AR expression (p=0.66; Mann-Whitney U-test). Nuclear staining for AR was positive in 10 of the 25 (40%) cancers, in the glandular cancer cells, in the surrounding stroma and in the myometrium. There was a significant correlation between mRNA RT-PCR AR expression and the IHC AR staining in endometrial tumors (r=0.53; p=0.006).
Conclusion:
To the best of our knowledge, this is the first description of AR expression in both normal and pathological changes of the human endometrium using the RT-PCR techniques. Our observations confirmed the role of the AR in the stromal regulation of epithelial cells within the neoplastic endometrium.
