2-triazenoindoles: synthesis and biological activity
Paola Barraja1, Patrizia Diana, Antonino Lauria
1Dipartimento Farmacochimico Tossicologico e Biologico, Università degli Studi, Palermo, Italy.
Anticancer Research
|May 17, 2002
Abstract:
A series of 2-triazenoindole derivatives was prepared in moderate to good yields by coupling 2-diazoindoles with secondary amines. Only 3-ethoxycarbonyl-2-(3.3-tetramethylenetriazenyl)-indole, tested against a panel of 60 human tumor cell lines, showed moderate activity on breast, ovarian and CNS cancer with GI50 in the range 23-36 microM.
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