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Related Experiment Videos

Reviewing interval cancers: time well spent?

Kate Gower-Thomas1, Hilary M P Fielder, Lucy Branston

  • 1Breast Test Wales, 18 Cathedral Road, Cardiff CF11 9LJ, UK.

Clinical Radiology
|May 17, 2002
PubMed
Summary

False-negative rates for interval breast cancers were lower in incident screens (18%) compared to prevalent screens (36%). This suggests fewer cancers were present at incident screens, not necessarily a failure to detect tumors.

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Area of Science:

  • Radiology
  • Oncology
  • Public Health

Background:

  • Interval cancers are breast cancers diagnosed between routine screening mammograms.
  • Identifying false-negatives in mammographic screening is crucial for improving early detection rates.
  • The Welsh breast screening programme aimed to categorize interval cancers to assess screening effectiveness.

Purpose of the Study:

  • To categorize interval cancers identified after prevalent and incident screens within the Welsh breast screening programme.
  • To determine the rate of false-negatives in mammographic screening for breast cancer.

Main Methods:

  • A review of 560 interval breast cancers diagnosed between 1989 and 1997.
  • Screening films were blindly reviewed by eight radiologists, comparing them against symptomatic films.

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  • Interval cancers were classified according to National Health Service Breast Screening Programme (NHSBSP) guidelines.

    • Main Results:

    • 32% of classifiable interval films were categorized as false-negatives.
    • False-negative rates were significantly lower following incident screens (18%) compared to prevalent screens (36%).
    • Forty percent of the 'seed' films (films of women who developed interval cancer) were recalled by the review panel.

    Conclusions:

    • Lower false-negative rates in incident screens suggest fewer cancers were present, rather than missed detection.
    • The panel method for categorizing interval cancers has limitations and variability.
    • The findings indicate potential areas for improvement in breast cancer screening protocols.