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[Study of radiation synovectomy using (188)Re-Sulfide in hemophilic arthritis]
Peiyong Li1, Gang Chen, Liying Zhang
1Department of Nuclear Medicine of Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China.
Objective:
To study the effectiveness of radiation synovectomy with (188)Re-sulfide.
Methods:
Twenty rabbit models of joint synovitis were injected intra-articularly with different doses of (188)Re-sulfide from 7.4 to 37.0 MBq. By pathological examination, the effects of (188)Re-sulfide on synovium and cartilage were evaluated. Clinically, 10 joints of 7 cases of hemophilic arthritis with (188)Re-sulfide radiation synovectomy were performed. MRI was taken before and after the synovectomy to evaluate the treatment effects.
Results:
In rabbit models, when (188)Re-sulfide dose larger than 14.8 MBq, the radiation effect on synovitis was remarkable, including thinning the thickened synovium and reducing the inflammatory cells. When radio-activity dose increased to 37.0 MBq, pathological damage was noted in cartilage. Clinical trial demonstrated that radiation synovectomy by (188)Re-sulfide could reduce the frequencies of intra-articular hemorrhage. MRI showed that edema and villi reduced.
Conclusions:
Radiation synovectomy using (188)Re-sulfide is effective on synovitis in hemophilic arthritis.