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Updated: Aug 14, 2026

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
[A case-control study on family history of Alzheimer's disease]
Jiahong Yao1, Hui Li, Zhenxin Zhang
1Department of Epidemiology, Institute of Basic Medical Sciences, CAMS & PUMC, Beijing 100005, China.
Objective:
To explore the relationship between Alzheimer's disease and its family history of the patients.
Methods:
Stratified analyses and logistic regression analysis were used to examine the association between Alzheimer's disease and its family history exposure in 127 cases and 254 matched controls from a population-based case-control study.
Results:
The risk of Alzheimer's disease was significantly higher in those who had at least one first-degree relative with dementia or major psychosis as compared to those who had no dementia or major relatives with psychosis (OR = 6.25; 8.33). Adjusted for age and level of education, family history of dementia was still associated with Alzheimer's disease positively (OR = 2.07).
Conclusion:
This study provides evidence that familial aggregation of Alzheimer's disease might exist among people living Beijing.
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