Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chronic hyperbaric exposure activates proinflammatory mediators in humans.

Anders Ersson1, Maria Walles, Kjell Ohlsson

  • 1Department of Anesthesiology, University Hospital, Malmoe General Hospital, 205 02 Malmoe, Sweden. anders.ersson@skane.se

Journal of Applied Physiology (Bethesda, Md. : 1985)
|May 17, 2002
PubMed
Summary

Divers showed inflammatory activation after daily diving, indicated by increased interleukin-8 (IL-8) and neutrophil gelatinase-associated lipocalcin (NGAL) levels, alongside decreased secretory leukocyte protease inhibitor (SLPI). This suggests a compensated inflammatory response without losing homeostasis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Health-related quality of life, physical and mental capacity at one year follow up of COVID-19 ICU patients: A prospective cohort study.

Journal of patient-reported outcomes·2025
Same author

Lipid oxidation inhibition capacity of plant extracts and powders in a processed meat model system.

Meat science·2019
Same author

Lipid Oxidation Inhibition Capacity of 11 Plant Materials and Extracts Evaluated in Highly Oxidised Cooked Meatballs.

Foods (Basel, Switzerland)·2019
Same author

Effects of a multifaceted intervention QI program to improve ICU performance.

BMC health services research·2018
Same author

Driving for successful change processes in healthcare by putting staff at the wheel.

Journal of health organization and management·2018
Same author

Antioxidant capacity and major phenol compounds of horticultural plant materials not usually used.

Journal of functional foods·2017

Area of Science:

  • Physiology
  • Diving Medicine
  • Immunology

Background:

  • Decompression illness (DCI) is a risk for divers due to pressure changes.
  • An inflammatory mechanism, beyond mechanical factors, is proposed to contribute to DCI.
  • Biomarkers of inflammation and leukocyte activation are crucial for understanding DCI pathogenesis.

Purpose of the Study:

  • To investigate inflammatory markers in asymptomatic divers undergoing daily diving for two months.
  • To assess changes in interleukin-8 (IL-8), IL-6, IL-1 receptor antagonist (IL-1ra), secretory leukocyte protease inhibitor (SLPI), and neutrophil gelatinase-associated lipocalcin (NGAL).

Main Methods:

  • Measurement of IL-8, IL-6, IL-1ra, SLPI, and NGAL in military divers before and after a 2-month daily diving regimen.
  • Divers were monitored for clinical symptoms of DCI throughout the study period.

Related Experiment Videos

Main Results:

  • Significant increases in IL-8 and NGAL levels were observed.
  • A significant decrease in SLPI levels was noted.
  • No significant changes were found in IL-6 and IL-1ra levels, indicating a lack of severe inflammatory response.

Conclusions:

  • The study indicates a compensated activation of the inflammatory defense mechanism in divers.
  • Increased NGAL and IL-8 suggest leukocyte activation, while decreased SLPI points to an influence on inflammatory defense.
  • The findings suggest that the inflammatory system maintains homeostasis despite daily diving stress.