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[Immunogenicity of retina in mice]
1Department of Ophthalmology, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
Objective:
To evaluate the immunogenicity of retina.
Methods:
DBA/2 mice (MHCH-2d) were used as donors, C57BL/6 mice (MHC H-2d) or BALB/C mice (MHC H-2d) as recipients. Half retina of DBA/2 mouse was transplanted subcutaneously to a C57BL/6 or BALB/C mouse. The delayed-type hypersensitivity (DTH) and specific killing rate of cytotoxic T lymphocyte(CTL) were detected two weeks later.
Results:
The results of DTH and specific killing rate of CTL in the retina of DBA/2 mice were significantly lower than the positive group(P < 0.01), but significantly higher than the negative group(P < 0.01).
Conclusion:
MHC Class I and Class II antigen and minor histocompatibility complex antigen(Minor HC) are expressed in the retina of the DBA/2 mouse, which stimulates immune system of recipient to produce weak cellular immune response. It is suggested that the retina has weak immunogenicity.