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The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension
Published on: May 17, 2024
[Synthesis of 1,4-dihydropyridines with blood pressure and blood-fat lowering effects]
Abstract:
To develop new drugs with the effects of lowering blood-fat and blood pressure, compounds 1-7 and 10 were synthesized by the reactions of 2-methyl-2-[4-(4-chlorobenzoyl)phenoxy]propionyl chloride with a hydroxyl group in 1,4-dihydropyridines. Compounds 8 and 9 were obtained by the reactions of 2-methyl-2-[4-(4-chlorobenzoyl)phenoxy]propionyl chloride with salicylic aldehyde first, and then with beta-aminocrotonates. All 1-10 are new compounds, and their structures were elucidated by means of 1HNMR and MS. The effects of compounds 1-10 on lowering cholesterol, triglyceride and blood pressure were investigated, and some of which were found to have the effects of lowering triglyceride and blood pressure.
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