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Updated: Oct 1, 2026
Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
Published on: January 28, 2021
[Effects of isorhapotigenin and resveratrol on function of peripheral blood polymorphonuclear leukocytes from
1Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050.
Abstract:
In effects of isorhapotigenin and resveratrol on chemotaxis and release of beta-glucuronidase from rabbit peripheral blood polymorphonuclear leukocytes stimulated with formylmethionyl-leucyl-phenyl-phenylalanine (fMLPP) were studied. The optimal concentration of fMLPP for the induction of chemotaxis of polymorphonuclear leukocytes was approximately at 5 x 10(-10) mol.L-1. fMLPP, at the concentration range of 10(-10)-10(-6) mol.L-1, dose-dependently increased the release of beta-glucuronidase from polymorphonuclear leukocytes. Isorhapotigenin and resveratrol both inhibited the chemotaxis of polymorphonuclear leukocytes stimulated with fMLPP(5 x 10(-10) mol.L-1). Isorhapotigenin, at the concentration range of 10(-5)-10(-4) mol.L-1, dose-dependently inhibited the release of beta-glucuronidase from polymorphonuclear leukocytes stimulated with fMLPP(10(-8) mol.L-1). Resveratrol, at the concentrations of 1 x 10(-5) and 3 x 10(-5) mol.L-1, was shown to dose-dependently inhibit beta-glucuronidase release from polymorphonuclear leukocytes stimulated with fMLPP(10(-8) mol.L-1).
