[Synthesis and biological activity of 1-(4-acylamino)benzyl-1,2,3,4-tetrahydroisoquinolines]

L He1, W Huang, Y Shen

  • 1Division of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009.

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Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
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Diazonium Group Substitution: –OH and –H

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