Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in guinea-pig dermal collagen during development.

C A Shuttleworth, L Forrest

    European Journal of Biochemistry
    |July 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Dementia knowledge transfer project in a rural area.

    Rural and remote health·2013
    Same author

    Prediction in breast cancer of the extent of axillary node involvement from the size and lymphovascular invasion status of the primary tumour: medico-legal considerations.

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2006
    Same author

    Completion thyroidectomy and thyroglobulin measurement in the management of metastatic differentiated thyroid cancer.

    Thyroid : official journal of the American Thyroid Association·2006
    Same author

    Fibrillin-rich microfibrils: elastic biopolymers of the extracellular matrix.

    Journal of muscle research and cell motility·2003
    Same author

    Arteriovenous fistula of the lateral superior and inferior geniculate arteries. A unique cause of a "recurrent prepatellar bursa.

    International angiology : a journal of the International Union of Angiology·2002
    Same author

    Upregulation of collagen VIII following porcine coronary artery angioplasty is related to smooth muscle cell migration not angiogenesis.

    International journal of experimental pathology·2001
    Same journal

    Comparison of expression patterns and cell adhesion properties of the mouse biliary glycoproteins Bgp1 and Bgp2.

    European journal of biochemistry·2020
    Same journal

    AB 3.1.1.1 (or EC 3.1.1.?).

    European journal of biochemistry·2020
    Same journal

    Cdk5.

    European journal of biochemistry·2018
    Same journal

    Structure of the core oligosaccharide of a rough-type lipopolysaccharide of Pseudomonas syringae pv. phaseolicola.

    European journal of biochemistry·2004
    Same journal

    Monitoring ligand-mediated nuclear receptor-coregulator interactions by noncovalent mass spectrometry.

    European journal of biochemistry·2004
    Same journal

    Solution structure of long neurotoxin NTX-1 from the venom of Naja naja oxiana by 2D-NMR spectroscopy.

    European journal of biochemistry·2004
    See all related articles

    Type III collagen shows high activity in early fetal development, decreasing significantly later. Type I collagen

    Area of Science:

    • Biochemistry
    • Developmental Biology

    Background:

    • Collagen is a crucial structural protein in connective tissues.
    • Type I and Type III collagens are major fibrillar collagens with distinct roles.

    Purpose of the Study:

    • To investigate the developmental changes in Type I and Type III collagen synthesis.
    • To compare the specific activity of newly synthesized Type I and Type III collagens during fetal development.

    Main Methods:

    • Pepsin digestion of guinea-pig dermis to solubilize collagen.
    • Differential salt precipitation for collagen type separation.
    • Radioactive proline incorporation to label newly synthesized collagen.
    • Amino acid analysis and subunit composition comparison.

    Main Results:

    Related Experiment Videos

    • Distinct differences in subunit composition and amino acid profiles between Type I and Type III collagen were observed.
    • Type III collagen exhibited high specific activity in early fetal development, which declined substantially as development progressed.
    • The specific activity of pepsin-solubilized Type I collagen remained relatively constant throughout fetal development.

    Conclusions:

    • The synthesis rate of Type III collagen is significantly higher during early fetal development compared to Type I collagen.
    • These findings highlight differential regulation of collagen synthesis during development.
    • Type III collagen plays a more prominent role in early tissue formation.