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Updated: Aug 14, 2026

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Published on: November 8, 2011
Persistent polyclonal B-cell lymphocytosis
L Ide1, A Dekoninck, E Verburgh
1Department of Haematology, Laboratory Medicine, University Hospital Gasthuisberg, Leuven, Belgium. Nancy.Boeckx@uz.kuleuven.ac.be
Persistent polyclonal B-cell lymphocytosis (PPBL) is a rare syndrome. This case highlights a patient with PPBL, featuring atypical lymphocytes, elevated IgM, and a history of EBV infection, with no signs of malignancy.
Area of Science:
- Hematology
- Immunology
- Oncology
Background:
- Persistent polyclonal B-cell lymphocytosis (PPBL) is a rare non-malignant lymphoproliferative disorder.
- It is characterized by sustained peripheral blood lymphocytosis with specific morphological features.
Observation:
- The case involved a patient with serological evidence of prior Epstein-Barr virus (EBV) infection.
- The patient presented with elevated polyclonal serum IgM levels.
- Heavy smoking history was noted in the patient.
Findings:
- Circulating atypical binucleated lymphocytes were a key finding.
- Diagnostic workup excluded any underlying B-cell malignancy.
- The lymphocytosis was polyclonal, indicating a reactive process.
Implications:
- This case contributes to understanding the clinical spectrum of PPBL.
- It underscores the importance of differentiating PPBL from lymphoproliferative malignancies.
- Further research may elucidate the role of EBV and environmental factors in PPBL pathogenesis.
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