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Inositol polyphosphate 5-phosphatases: lipid phosphatases with flair
Christina A Mitchell1, Rajendra Gurung, Anne M Kong
1Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia. Christina.Mitchell@med.monash.edu.au
IUBMB Life
|May 23, 2002
Abstract:
Recent studies have identified the inositol polyphosphate 5-phosphatases as a large family of signal modifying enzymes comprising 10 mammalian and 4 yeast family members. A number of investigations including gene-targeted deletion of 5-phosphatases in mice have demonstrated that these enzymes regulate many important cellular events including hematopoietic cell proliferation and activation, insulin signaling, endocytosis, and actin polymerization.