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06:01
A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
Published on: July 6, 2017
Calcium-sensing receptor A986S polymorphism in human rectal cancer
11st Department of Medicine, Semmelweis University Budapest, Hungary. speerga@bell.sote.hu
International Journal of Colorectal Disease
|May 23, 2002
Summary
The calcium-sensing receptor (CaSR) A986S polymorphism may influence rectal cancer progression. Patients with the AA genotype showed higher cancer stages and a tendency for poor prognosis, especially with coexpressed oncogenes.
Area of Science:
- Oncology
- Genetics
- Molecular Biology
Background:
- Calcium ions (Ca2+) exhibit protective effects against colorectal cancer.
- The calcium-sensing receptor (CaSR) detects extracellular Ca2+ levels.
- The CaSR A986S polymorphism is linked to serum calcium variations, with the AA genotype associated with lower levels.
Purpose of the Study:
- To investigate the association between the CaSR A986S polymorphism and the expression of oncogenes (erbB-2, EGFR, p53, ras) and tumor stage in rectal cancer patients.
Main Methods:
- Genotyping for the CaSR A986S polymorphism in 56 rectal cancer patients and 112 controls.
- Assessed the expression of erbB-2, EGFR, p53, and ras.
- Correlated genotype with tumor-node-metastasis (TNM) or Union for International Cancer Control (UICC) stage and patient prognosis.
Main Results:
- No significant difference in AA genotype frequency between cancer patients and controls.
- Patients with the AA genotype showed significantly higher UICC stages when major oncogenes were coexpressed.
- The AA genotype indicated a trend towards poorer prognosis during follow-up.
Conclusions:
- Genetic variations in the CaSR may play a role in the development and progression of rectal cancer.
- The CaSR A986S polymorphism, particularly the AA genotype, could be a potential biomarker for advanced disease and prognosis in rectal cancer.
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