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Recombinant mycobacterial proteins future directions to improve protective efficacy
1Department of Biochemistry, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Indian Journal of Experimental Biology
|May 23, 2002
Abstract:
A large number of subunit vaccine candidates have recently been developed as alternatives to Mycobacterium bovis Bacillus Calmette-Guerin (BCG), which gives unpredictable and highly variable protection against tuberculosis. Immunological potential of various recombinant proteins against mycobacterial infections has been discussed. Further, strategies have been suggested, which include development of constructs coexpressing cytokines or regimens utilizing recombinant proteins for further improving the protective efficacy.