Related Experiment Video
Updated: Aug 6, 2026

The Forced Swim Test as a Model of Depressive-like Behavior
Published on: March 2, 2015
Antidepressant activity of hyperforin conjugates of the St. John's wort, Hypericum perforatum Linn.: an experimental
A V Muruganandam1, S K Bhattacharya, S Ghosal
1Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Abstract:
Nine extracts of H. perforatum, containing hyperforin in conjugated forms, but devoid of free hyperforin and adhyperforin, were subjected to antidepressant screening using the forced swim test (FST). The observed activity was compared with that of SJW extracts containing hyperforin and adhyperforin (in free form). Results indicate that hyperforin conjugates exhibit significant antidepressant activity as evidenced by the reduced immobility period in the FST in rats.
More Related Videos
Related Concept Videos
Antidepressant Drugs: Overview
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
Antidepressant Drugs: MAOIs and Other Agents

