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Molecular characterization of the vanE gene cluster in vancomycin-resistant Enterococcus faecalis N00-410 isolated in
D A Boyd1, T Cabral, P Van Caeseele
1Nosocomial Infections, National Microbiology Laboratory, Health Canada, Winnipeg, Manitoba, Canada.
Antimicrobial Agents and Chemotherapy
|May 23, 2002
Abstract:
The vanE operon was characterized from Enterococcus faecalis N00-410 (MIC of vancomycin = 24 microg/ml). The organization of the vanE operon was identical to that of the vanC1 operon from Enterococcus gallinarum, with protein identities ranging from 46 to 63%. An open reading frame located downstream of the vanE operon showed significant homology to a number of integrase genes, all of which are located downstream of the chromosomal GMP synthase gene guaA.