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Related Experiment Videos

Nonadherence with mood stabilizers: prevalence and predictors.

Jan Scott1, Marie Pope

  • 1University of Glasgow, Scotland. jan.scott@clinmed.gla.ac.uk

The Journal of Clinical Psychiatry
|May 22, 2002
PubMed
Summary

High rates of mood stabilizer nonadherence are prevalent in individuals with affective disorders. Patient attitudes and behaviors, not side effects, are key predictors, necessitating routine clinical inquiry.

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Area of Science:

  • Psychiatry
  • Pharmacology
  • Clinical Psychology

Background:

  • Mood stabilizer nonadherence affects 18%-52% of patients.
  • Limited research addresses mood stabilizer nonadherence.
  • Affective disorders require long-term mood stabilizer treatment.

Purpose of the Study:

  • To determine the prevalence of mood stabilizer nonadherence.
  • To identify predictors of nonadherence in patients with affective disorders.

Main Methods:

  • Studied 98 patients with major depressive disorder or bipolar disorder on lithium, carbamazepine, or valproate.
  • Utilized biochemistry lab data to identify subjects.
  • Conducted structured clinical interviews to assess adherence and influencing factors.

Main Results:

  • Nearly 50% reported nonadherence in the past 2 years; 32% reported partial adherence in the last month.
  • Predictors of partial adherence included past nonadherence, denial of illness severity, and longer duration of mood stabilizer prescription.
  • Attitudes and behaviors were stronger predictors than medication side effects.

Conclusions:

  • Mood stabilizer nonadherence is a significant clinical issue.
  • Patient attitudes and behaviors are crucial predictors of nonadherence.
  • Clinicians should routinely assess medication adherence.

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