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Autopsy-proven, sporadic pick disease with onset at age 25 years
Landon W Coleman1, Kathleen B Digre, Gary M Stephenson
1Department of Pathology, University of Utah Health Sciences Center, 30 N 1900 East, Salt Lake City, UT 84132-2501, USA.
Context:
Pick disease is uncommon and accounts for less than 2% of adult-onset dementias. Reports of Pick disease in young adults have apparently increased in the last decade.
Objective:
To document the presentation and course of a patient with tau-positive Pick disease presenting at an extremely young age.
Setting:
A university hospital.
Patient:
A white woman with cognitive impairment that began at age 25 years. She experienced progressive dementia over an 8-year period with radiographic evidence of severe cerebral atrophy of the frontotemporal lobes. Autopsy findings confirmed the diagnosis of Pick disease characterized by tau-positive Pick bodies in the neurons of the fascia dentata.
Conclusion:
Pick disease should be considered in the differential diagnosis of young adults presenting with behavioral symptoms, especially those of frontal impairment.