Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aging facilitates long-trace taste-aversion conditioning in rats.

James R Misanin1, Michele Collins, Scott Rushanan

  • 1Susquehanna University, Selinsgrove, PA 17870, USA. misanin@susqu.edu

Physiology & Behavior
|May 22, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Influence of Fixation Stiffness on Bone Regeneration in a Rodent Bone Critical Size Defect Model.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2026
Same author

HIF1α controls somitogenesis and spine development by regulating levels of intracellular oxygen in the presomitic mesoderm.

bioRxiv : the preprint server for biology·2026
Same author

Use of an Electronic Health Record-Embedded Glycemic Management Protocol to Improve Perioperative Glucose Control in People With Diabetes.

Journal of diabetes science and technology·2025
Same author

The association between prehabilitation participation and spine surgery outcomes.

Clinical neurology and neurosurgery·2025
Same author

Improvements in micelle promoted DNA-encoded library synthesis by surfactant optimisation.

Organic & biomolecular chemistry·2025
Same author

Response to Wu et al.

Differentiation; research in biological diversity·2025

Older rats show stronger taste aversion learning, especially with longer delays between stimuli. This suggests aging impacts conditioning, possibly due to a slower internal biological clock.

Area of Science:

  • Neuroscience
  • Behavioral Psychology
  • Animal Cognition

Background:

  • Long-trace conditioning involves a temporal gap between a conditioned stimulus (CS) and an unconditioned stimulus (US).
  • Age-related cognitive changes can affect learning and memory processes.
  • Understanding these changes is crucial for gerontology and comparative psychology.

Purpose of the Study:

  • To investigate age-related differences in long-trace taste-aversion conditioning.
  • To determine how varying conditioned stimulus-unconditioned stimulus (CS-US) intervals influence learning across different age groups.

Main Methods:

  • Utilized five age groups of Wistar-derived female albino rats (0.25 to 2.5 years).
  • Employed taste-aversion conditioning with five CS-US intervals (0, 45, 90, 180, 360 min).

Related Experiment Videos

  • Measured the strength of conditioned aversion as an indicator of learning.

    • Main Results:

    • Significant age differences in aversion strength were observed at CS-US intervals exceeding 0 min.
    • A stronger aversion was directly correlated with increasing age of the rats.
    • Successful conditioning at a 360-min CS-US interval was limited to the two oldest age groups.

    Conclusions:

    • Aging significantly influences long-trace conditioning, with older rats exhibiting superior performance.
    • The findings suggest that age-related physiological changes, such as a slowing metabolic pacemaker, may underlie these conditioning differences.
    • This research provides insights into the neurobiology of aging and learning in mammals.