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A new model for analyzing immunomodulation of T cell responses induced by oral administration of islet cell antigens

Søren Bregenholt1, Mikala Wang, Maja Zdravkovic

  • 1Islet Discovery Research and Clinical Drug Development, Novo Nordisk, Novo Alle, Bagsvaerd, Denmark. sqbr@novonordisk.com

Annals of the New York Academy of Sciences
|May 22, 2002
PubMed

Based on the coimmunization of BALB/c mice with insulin and ovalbumin, we here describe a feasible efficacy model for analyzing the tolerogenic effect of the oral administration of sequestered antigens-for example, islet-specific proteins such as insulin and GAD65.

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