Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Perspective: prostate cancer susceptibility genes.

Jacques Simard1, Martine Dumont, Penny Soucy

  • 1Oncology and Molecular Endocrinology Research Center, CHUL Research Center and Laval University, Québec City, G1V 4G2, Canada. Jacques.Simard@crchul.laval.ca

Endocrinology
|May 22, 2002
PubMed
Summary

Prostate cancer genetic susceptibility is complex due to late diagnosis and genetic heterogeneity. Researchers identified ELAC2 and RNASEL genes as potential risk factors, but further studies are needed.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of a one-step sample preparation protocol for analysis of total serum testosterone by LC-MS/MS.

Clinical mass spectrometry (Del Mar, Calif.)·2024
Same author

Canadian Healthcare Professionals' Views and Attitudes toward Risk-Stratified Breast Cancer Screening.

Journal of personalized medicine·2023
Same author

Evaluation of European-based polygenic risk score for breast cancer in Ashkenazi Jewish women in Israel.

Journal of medical genetics·2023
Same author

Contralateral breast cancer risk in patients with breast cancer and a germline-BRCA1/2 pathogenic variant undergoing radiation.

Journal of the National Cancer Institute·2023
Same author

Regulating cancer risk prediction: legal considerations and stakeholder perspectives on the Canadian context.

Human genetics·2023
Same author

Associations of height, body mass index, and weight gain with breast cancer risk in carriers of a pathogenic variant in BRCA1 or BRCA2: the BRCA1 and BRCA2 Cohort Consortium.

Breast cancer research : BCR·2023

Area of Science:

  • Urology
  • Genetics
  • Oncology

Background:

  • Prostate cancer is a leading malignancy in developed countries with unknown racial/ethnic incidence differences.
  • Family history is a strong risk factor, but identifying genetic markers for prostate cancer is challenging due to late diagnosis and genetic heterogeneity.

Purpose of the Study:

  • To investigate genetic factors contributing to prostate cancer susceptibility.
  • To identify and evaluate candidate genes associated with increased prostate cancer risk.

Main Methods:

  • Positional cloning and linkage analysis were used to identify susceptibility loci.
  • Candidate gene analysis, including ELAC2 and RNASEL, was performed.
  • Association studies examined common genetic variants in genes like 5alpha-reductase type 2 and AR.

Related Experiment Videos

Main Results:

  • The ELAC2 gene was identified as the first prostate cancer susceptibility gene.
  • Deleterious mutations in the RNASEL gene were found in some high-risk families.
  • Common genetic variants in 5alpha-reductase type 2 and AR genes showed significant associations with prostate cancer risk.

Conclusions:

  • Identifying prostate cancer susceptibility genes is complex but crucial.
  • ELAC2 and RNASEL are important candidate genes requiring further validation.
  • Both rare high-penetrance mutations and common low-penetrance variants likely contribute to familial prostate cancer risk.