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Related Experiment Videos

Hypercoagulability in childhood cancer.

W E Hathaway, T Hays

    Journal of Pediatric Surgery
    |December 1, 1975
    PubMed
    Summary

    Childhood solid tumors can cause hypercoagulability, indicated by abnormal thrombelastograms and elevated factor VIII. Disseminated intravascular coagulation was uncommon in these pediatric cancer patients.

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    Area of Science:

    • Pediatric Oncology
    • Hematology
    • Coagulation Disorders

    Background:

    • Solid tumors are prevalent in children.
    • Coagulation abnormalities can complicate cancer treatment.
    • Understanding hypercoagulability in pediatric solid tumors is crucial.

    Purpose of the Study:

    • To investigate coagulation alterations in children with solid tumors.
    • To assess the prevalence of hypercoagulability and disseminated intravascular coagulation.

    Main Methods:

    • Studied 32 children with various solid tumors.
    • Assessed platelet counts, aggregation, thrombelastogram, factor VIII, fibrin split products, and antithrombin III levels.

    Main Results:

    • Approximately 50% of patients exhibited hypercoagulability.
    • Elevated factor VIII levels and platelet counts were observed.
    • Increased fibrin split products were noted in one-third of patients; disseminated intravascular coagulation was rare.

    Conclusions:

    • Hypercoagulability is a significant finding in pediatric solid tumors.
    • This contrasts with the more common disseminated intravascular coagulation in some adult cancers.
    • Pediatric sarcoma patients can present with hypercoagulability similar to adult carcinoma patients.

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