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Growth dynamics of meningiomas in patients with multiple sclerosis treated with interferon: report of two cases
1Department of Neurosurgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Background:
Although multiple sclerosis (MS) is a common disease of the central nervous system, the association of intraparenchymal tumour has been rarely reported and the potential relationship between intracranial meningioma and MS has not been seriously analysed. This report addresses the association of multiple sclerosis and intracranial meningioma and discusses the effect of interferon treatment on tumour progression.
Clinical Presentation:
We report two cases with multiple sclerosis, who developed meningioma four and twenty years after the diagnosis of MS was made. Neither patient had a history of meningioma initially and both were being treated interferon when the meningioma was progressed.
Findings:
Histological examination of two cases revealed meningothelial meningioma. The first patient's KI67 level was 2.5% and was positive for the progesterone and estrogen receptor. Chromosomal analysis showed some abnormalities. In the second case, mild atypical change by presence of nuclear enlargement and rare mitotic figures were noted and PCNA, KI67 levels were less than 2%.
Conclusions:
We reported the association of multiple sclerosis and intracranial meningioma and observed the progression of the meningiomas during interferon treatment. Although, we cannot exclude the coincidence between the two diseases we discussed suspicious relationship between the interferon treatment and the tumour progression.
Insights
This study reports two cases of intracranial meningioma in patients with multiple sclerosis (MS). The meningiomas progressed during interferon treatment, suggesting a potential link between MS, meningioma, and interferon therapy.
Area of Science:
- Neuro-oncology
- Neurology
Background:
- Multiple sclerosis (MS) is a common central nervous system disease.
- The association between MS and intraparenchymal tumors is rare.
- The relationship between intracranial meningioma and MS requires further analysis.
Observation:
- Two cases of multiple sclerosis (MS) patients developed intracranial meningioma.
- Meningiomas appeared 4 and 20 years after MS diagnosis.
- Both patients received interferon treatment, during which meningioma progression was observed.
Findings:
- Histological examination revealed meningothelial meningioma in both cases.
- Tumor markers (KI67, progesterone/estrogen receptors, PCNA) and chromosomal analysis showed variations.
- One case exhibited mild atypical changes with nuclear enlargement and rare mitotic figures.
Implications:
- The study highlights a potential association between multiple sclerosis and intracranial meningioma.
- Observed meningioma progression during interferon treatment warrants further investigation.
- A possible link between interferon therapy and tumor progression in MS patients is suggested.
