Related Experiment Video
Updated: Oct 1, 2026

Enhancing the Development and Growth of Infant Cerebral Palsy Rats Using Selective Spinal Manipulations
Published on: February 2, 2024
[Repercussion of mental retardation and associated cerebral palsy on skeletal maturation]
J M Sánchez-Lastres1, J Eirís-Puñal, J L Otero-Cepeda
1Dpto. de Pediatría. Servicio de Neuropediatría; Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, 15705, España.
Insights
Fifty percent of children with mental retardation (MR) show delayed skeletal maturation. Factors like cerebral palsy, diet quality, and socio-familial aspects significantly impact bone development in this population.
Area of Science:
- Pediatric Endocrinology
- Nutritional Science
- Developmental Pediatrics
Context:
- Mental retardation (MR) affects 3% of children, yet its impact on nutritional status is understudied.
- Previous research on MR and nutrition has yielded conflicting results.
- Skeletal maturation is a key indicator of overall growth and development.
Purpose:
- To assess the nutritional status of mentally retarded children using skeletal maturation.
- To identify factors influencing bone age in this population.
Summary:
- A study of 128 mentally retarded children (aged 0-17) evaluated nutritional status and skeletal maturation.
- Bone age assessment in 53 children revealed a 50% prevalence of delayed skeletal maturation.
- Factors including cerebral palsy, MR severity, diet quality, and socio-familial environment significantly correlated with bone maturation delay.
Impact:
- Highlights the high prevalence of delayed bone maturation in mentally retarded children.
- Identifies critical factors influencing growth and development in this vulnerable group.
- Informs targeted nutritional and clinical interventions for children with mental retardation.
Introduction:
Mental retardation (MR) constitutes a clinical and social relevant condition accounting for 3% of the pediatric population. Studies focusing the repercussion of MR on nutritional status are scarce and, in occasions, have produced contradictory results.
Objective:
To evaluate the nutritional status of mentally retarded children in our Region, on the basis of skeletal maturation.
Patients And Methods:
Our sample comprise 128 mentally retarded children (81 boys and 47 girls) aged 0 17 years. In all children a nutritional and social family environment questionnaires and a valuation of a series of nutritional and anthropometric variables were performed. Additionally, bone age was assessed by means of left hand wrist radiograph in a subset of 53 children. A factorial analysis was carried out by means of the statistical package SPSS allowing the obtaining of 2 anthropometric factors and 3 biochemical factors that condensed the most information content. Results of the bone maturation were correlated with age, sex, presence of cerebral palsy (CP), severity of mental retardation, results of nutritional and sociofamilial questionnaire, antiepileptic treatment and nutritional status (anthropometric and biochemical factors).
Results:
Although a good correlation exists between bone age and chronological age, 50% of mentally retarded children presented delay in their skeletal maturation. The bone maturation was higher in the boys than in the girls. The presence of CP induced an increase of 12% in the delay of the skeletal maturation. The severity of MR induced differences in the bone age. Both quality of diet and score of anthropometric factor I inversely correlated with bone maturation delay. Parent s age and geographical precedence but not antiepileptic therapy affected the bone maturation.
Conclusions:
Delay in the bone maturation occurs with high prevalence among mentally retarded children. The presence of CP, severity of MR, quality of the diet and sociofamilial and nutritional factors influenced in an outstanding way in the bone maturation.
Related Concept Videos
Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Principles of Development
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Teratogenicity
Physical Growth During Infancy and Toddlerhood
Nature and Nurture
