Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Landau kleffner syndrome].

M J Pablo1, J R Valdizán, P Carvajal

  • 1Servicio de Neurofisiología, Hospital Universitario Miguel Servet, Zaragoza, 50009, España.

Revista De Neurologia
|May 22, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prior MRI-imaging impact of patients submitted to brachytherapy for prostate cancer.

Actas urologicas espanolas·2023
Same author

The synthetic molecule stauprimide impairs cell growth and migration in triple-negative breast cancer.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2022
Same author

High rate of autonomic neuropathy in Cornelia de Lange Syndrome.

Orphanet journal of rare diseases·2021
Same author

A simulation study of gold nanoparticles localisation effects on radiation enhancement at the mitochondrion scale.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2019
Same author

Anomalous mechanical behavior of nanocrystalline binary alloys under extreme conditions.

Nature communications·2018
Same author

Th1/Th17/Th22 immune response and their association with joint pain, imagenological bone loss, RANKL expression and osteoclast activity in temporomandibular joint osteoarthritis: A preliminary report.

Journal of oral rehabilitation·2018

Landau Kleffner syndrome (SLK) is a rare neurological disorder. This case presents a variant of SLK without seizures, showing some improvement with carbamazepine treatment.

Area of Science:

  • Neurology
  • Pediatric Neurology
  • Clinical Neuroscience

Background:

  • Landau Kleffner syndrome (SLK) is characterized by EEG abnormalities, acquired aphasia, and epilepsy.
  • Associated features include behavioral changes, cognitive regression, and motor dysfunction.
  • Standard antiepileptic drug treatments are often ineffective for SLK.

Observation:

  • A 5-year-old boy presented with behavioral changes and aphasia at age 4.
  • EEG and polysomnogram revealed paroxysmal changes, particularly during sleep.
  • Cranial CT identified a midline cyst; no epileptic seizures were observed.

Findings:

  • Carbamazepine treatment improved behavior and reduced EEG paroxysms, including the emergence of sleep spindles.
  • Aphasia showed minimal improvement despite treatment.

Related Experiment Videos

  • The case represents a variant of SLK lacking overt seizures and associated with a midline cyst.

    • Implications:

    • This case highlights a variant of Landau Kleffner syndrome without seizures, expanding the clinical spectrum of the disorder.
    • The partial response to carbamazepine suggests potential therapeutic avenues for specific SLK variants.
    • Further research is needed to understand the pathophysiology of seizure-free SLK variants and optimize treatment strategies.