Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Monotherapy using gabapentin in epilepsy].

J Sancho-Rieger1, J López-Trigo

  • 1Servicio de Neurología; Hospital General Universitario de Valencia, Valencia, 46014, España. med001942@saludalia.com

Revista De Neurologia
|May 22, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erratum to "Safety, efficacy and outcome-related factors of perampanel over 12months in a real-world setting: The FYDATA study" [Epilepsy Res. 126 (2016) 201-210].

Epilepsy research·2016
Same author

Safety, efficacy and outcome-related factors of perampanel over 12 months in a real-world setting: The FYDATA study.

Epilepsy research·2016
Same author

Validation of a short useful questionnaire in Spanish for the epidemiological screening of epilepsy in Spain. EPIBERIA Questionnaire.

Neurologia (Barcelona, Spain)·2012
Same author

Drug-resistant epilepsy: current recommendations for diagnosis and treatment in Spain.

Neurologia (Barcelona, Spain)·2011
Same author

Consensus-recommended diagnostic and therapeutic guidelines for drug-resistant epilepsy in Spain (Consenso RATE-España).

Neurologia (Barcelona, Spain)·2011
Same author

[Assessment of the efficiency of the clinical management of neuropathic pain in specialist clinics compared to general clinics in neurology health care units in Spain].

Neurologia (Barcelona, Spain)·2010

Gabapentin monotherapy effectively treated partial seizures in a two-year study. Most patients maintained treatment, with significant seizure reduction observed in over two-thirds.

Area of Science:

  • Neurology
  • Clinical Pharmacology

Background:

  • Epilepsy is a common neurological disorder.
  • Partial seizures are a frequent type of epilepsy.
  • Monotherapy is often the preferred initial treatment approach.

Purpose of the Study:

  • To evaluate the long-term efficacy and tolerability of gabapentin as monotherapy for partial seizures.
  • To assess the sustained effectiveness of gabapentin over a two-year period.

Main Methods:

  • A two-year prospective study involving 62 patients with partial seizures.
  • Patients were treated with gabapentin monotherapy.
  • Efficacy and tolerability were assessed over the study duration.
  • Literature review of published clinical trials and open studies was conducted.

Related Experiment Videos

Main Results:

  • 78% of patients remained on gabapentin monotherapy after two years.
  • 67.7% of patients experienced a >50% reduction in major seizures.
  • 11.1% of patients achieved complete seizure freedom.
  • Efficacy and tolerability remained consistent between the first and second years.

Conclusions:

  • Gabapentin is an effective and well-tolerated monotherapy for newly diagnosed epilepsy.
  • The study supports the long-term use of gabapentin in managing partial seizures.