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Recurrent central retinal vein occlusion in a young thrombophilic patient with factor V Leiden mutation
C Incorvaia1, F Bandello, F Parmeggiani
1Department of Ophthalmology, University of Ferrara, Italy.
Purpose:
To investigate the cause of recurrent central retinal vein occlusion in a 26-year-old white woman.
Methods:
Case report. Complete blood analyses were done, including HLA tissue typing, immunoserologic and coagulation tests, with cardiovascular and capillaroscopy investigations. Factor V:R506Q and prothrombin 20210 GIA mutations were checked by polymerase chain reaction and restriction enzyme analysis.
Results:
DNA analysis showed the patient to be heterozygous for factor V:R506Q mutation. During a follow-up of 18-months, after starting anticoagulant therapy, the patient had not suffered from any other ocular or systemic occlusive vascular accident.
Conclusions:
The R506Q factor V gene mutation may be associated with recurrent central retinal vein occlusions. Genetic investigation should be promptly recommended in thrombotic patients to establish a specific preventive treatment.