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Multifocal choroiditis after allogenic bone marrow transplantation
M T Alvarez1, J M Hernáez, E Ciancas
1Department of Ophthalmology, Ramón y Cajal University Hospital, Madrid, Spain.
European Journal of Ophthalmology
|May 23, 2002
Summary
Multifocal choroiditis can occur after allogenic bone marrow transplantation (BMT) in patients with chronic graft-versus-host disease (GVHD). Early detection and surgical intervention for choroidal neovascularization (CNV) are crucial for preserving vision.
Area of Science:
- Ophthalmology
- Hematology
- Immunology
Background:
- Allogenic bone marrow transplantation (BMT) can lead to graft-versus-host disease (GVHD), a significant complication.
- Self-tolerance to chronic GVHD may precede the development of ocular complications.
- Multifocal choroiditis is a rare but serious ocular condition.
Observation:
- A 17-year-old male developed multifocal choroiditis one year after BMT for chronic GVHD.
- Ophthalmoscopic examination revealed bilateral chorioretinal scars and vision loss.
- Fluorescein angiography identified choroidal neovascular membranes (CNVMs) in both eyes.
Findings:
- The patient experienced significant vision deterioration.
- Surgical removal of CNVMs in the right eye was performed.
- A subfoveal disciform scar was noted in the left eye.
Implications:
- Multifocal choroiditis should be considered a potential late complication of allogenic BMT.
- This condition represents a novel cause of BMT-associated choroidopathy.
- Surgical management of vision-threatening CNVMs is a viable treatment option.