Effect of breastfeeding on cognitive development of infants born small for gestational age

M R Rao1, M L Hediger, R J Levine

  • 1Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD 20892, USA. mr8u@nih.gov

Insights

Exclusive breastfeeding for 24 weeks significantly boosts cognitive development in infants born small for gestational age (SGA) without hindering growth. This duration is recommended to enhance intelligence quotient (IQ) in these infants.

Area of Science:

  • Pediatrics
  • Developmental Psychology
  • Nutritional Science

Background:

  • Breastfeeding benefits cognitive development, but its role for infants born small for gestational age (SGA) is unclear.
  • Infants born SGA may require nutritional supplementation for optimal growth.

Purpose of the Study:

  • To evaluate the impact of exclusive breastfeeding duration on cognitive development in term infants born SGA compared to those born appropriate for gestational age (AGA).

Main Methods:

  • Prospective evaluation of 220 term infants born SGA and 299 term infants born AGA.
  • Cognitive development assessed using Bayley Scale of Infant Development and Wechsler Preschool and Primary Scales of Intelligence.
  • Duration of exclusive breastfeeding and early nutritional supplementation were recorded.

Main Results:

  • Exclusive breastfeeding showed a greater positive effect on cognitive development in SGA infants than in AGA infants.
  • An 11-point IQ advantage was predicted for SGA infants exclusively breastfed for 24 weeks versus 12 weeks.
  • Growth of SGA infants was not negatively impacted by earlier nutritional supplementation.

Conclusions:

  • Exclusive breastfeeding duration significantly impacts cognitive development in SGA infants without compromising growth.
  • Exclusive breastfeeding for 24 weeks is recommended to enhance cognitive development in infants born SGA.
Abstract

Related Concept Videos

Anatomy of the Intestines01:23

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the small...
Biological Influences on Intelligence01:30

Biological Influences on Intelligence

Intelligence is often thought to be linked to brain size, but the relationship is more complex than that. While brain size does correlate modestly with some abilities, like verbal skills, the connection is weaker for others, such as spatial reasoning. Other factors, like brain structure, also play crucial roles. For instance, despite Einstein's smaller-than-average brain, his parietal cortex, which is involved in spatial reasoning, was 15% wider, suggesting that neural density might matter more...
Environmental Influences on Intelligence01:29

Environmental Influences on Intelligence

Despite the strong genetic influence on traits like intelligence, environmental factors significantly shape outcomes. For example, while over 90% of height variation is due to genetic differences, environmental factors such as nutrition also have a notable impact. Similarly, for intelligence, changes in a child's surroundings can significantly alter their IQ. Research shows that enriched environments boost children's academic success and help them develop key cognitive skills. Children from...
The Nativist Approach01:21

The Nativist Approach

The nativist approach to infant cognitive development proposes that infants are born with inherent knowledge structures that allow them to interpret the world almost immediately. This perspective contrasts with earlier developmental theories, such as those proposed by Jean Piaget, which emphasized a more gradual acquisition of cognitive abilities through interaction with the environment. One key concept in this approach is object permanence — the understanding that objects continue to exist...
Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
Gut-Brain Axis01:22

Gut-Brain Axis

The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...