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Effect of breastfeeding on cognitive development of infants born small for gestational age
M R Rao1, M L Hediger, R J Levine
1Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD 20892, USA. mr8u@nih.gov
Insights
Exclusive breastfeeding for 24 weeks significantly boosts cognitive development in infants born small for gestational age (SGA) without hindering growth. This duration is recommended to enhance intelligence quotient (IQ) in these infants.
Area of Science:
- Pediatrics
- Developmental Psychology
- Nutritional Science
Background:
- Breastfeeding benefits cognitive development, but its role for infants born small for gestational age (SGA) is unclear.
- Infants born SGA may require nutritional supplementation for optimal growth.
Purpose of the Study:
- To evaluate the impact of exclusive breastfeeding duration on cognitive development in term infants born SGA compared to those born appropriate for gestational age (AGA).
Main Methods:
- Prospective evaluation of 220 term infants born SGA and 299 term infants born AGA.
- Cognitive development assessed using Bayley Scale of Infant Development and Wechsler Preschool and Primary Scales of Intelligence.
- Duration of exclusive breastfeeding and early nutritional supplementation were recorded.
Main Results:
- Exclusive breastfeeding showed a greater positive effect on cognitive development in SGA infants than in AGA infants.
- An 11-point IQ advantage was predicted for SGA infants exclusively breastfed for 24 weeks versus 12 weeks.
- Growth of SGA infants was not negatively impacted by earlier nutritional supplementation.
Conclusions:
- Exclusive breastfeeding duration significantly impacts cognitive development in SGA infants without compromising growth.
- Exclusive breastfeeding for 24 weeks is recommended to enhance cognitive development in infants born SGA.
Unlabelled:
Breastfeeding during infancy appears to result in enhanced cognitive development during childhood, but it is not known whether breastfeeding should be encouraged for infants born small for gestational age (SGA) whose growth might otherwise benefit from nutritional supplementation. To address this issue, duration of exclusive breastfeeding and cognitive development were evaluated prospectively for 220 term children born SGA and 299 term children born appropriate for gestational age (AGA). Cognitive development was assessed using the Bayley Scale of Infant Development at 13 mo and Wechsler Preschool and Primary Scales of Intelligence at 5 y of age. Infants born SGA were given supplemental foods significantly earlier than those born AGA. Growth of infants born SGA was not related to early nutritional supplementation. The salutary effect of exclusive breastfeeding on cognitive development was greater for children born SGA than for those born AGA. Based on a linear association between duration of exclusive breastfeeding and intelligence quotient (IQ), children born SGA and exclusively breastfed for 24 wk were predicted to have an 11-point IQ advantage over those breastfed for 12 wk, as opposed to a 3-point advantage for children born AGA with similar durations of breastfeeding. The IQ distribution of children born SGA and exclusively breastfed for more than 12 wk was not different from that of all children born AGA.
Conclusion:
Duration of exclusive breastfeeding has a significant impact on cognitive development without compromising growth among children born SGA. These data suggest that mothers should breastfeed exclusively for 24 wk to enhance cognitive development.
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