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Updated: Aug 12, 2026

Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
Anaphylaxis after first exposure to ceftriaxone
M R Ernst1, P J van Dijken, P J Kabel
1Department of Paediatrics, St Elisabeth Hospital, Tilburg, The Netherlands.
Unlabelled:
Life-threatening anaphylaxis developed in a 5-y-old boy with septic shock within minutes of receiving his first intravenous injection of ceftriaxone. Hypersensivity could not be demonstrated by skin testing and ceftriaxone-specific IgE. However, an in vivo, controlled, intravenous challenge was clearly positive.
Conclusion:
Clinicians should be aware of the possibility of anaphylaxis occurring with the first dose of ceftriaxone, especially since such a reaction could go unnoticed in patients with life-threatening infections and unstable vital signs.
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