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Related Experiment Videos

Leflunomide-associated skin ulceration.

Christopher M McCoy1

  • 1Department of Pharmacy Practice, Bouve College of Health Sciences, Northeastern University, Boston, MA 02215-5400, USA. cmccoy@caregroup.harvard.edu

The Annals of Pharmacotherapy
|May 23, 2002
PubMed
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Leflunomide, used for rheumatoid arthritis, may cause skin ulceration. This is the first reported case linking this immunosuppressant drug to skin breakdown, similar to methotrexate.

Area of Science:

  • Rheumatology
  • Dermatology
  • Pharmacology

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease.
  • Immunosuppressant medications are used to manage RA.
  • Methotrexate is a known RA drug associated with skin ulceration.

Observation:

  • A 78-year-old woman developed bilateral leg ulcers after six months of leflunomide treatment for RA.
  • The patient had a prior history of leg ulcers with methotrexate therapy.
  • Diagnostic tests ruled out other causes for the skin ulceration.

Findings:

  • This case report suggests a potential association between leflunomide and skin ulceration.
  • Leflunomide is an immunosuppressant agent used for RA treatment.
  • Skin breakdown is a recognized adverse effect of immunosuppressants.

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Implications:

  • Leflunomide may be added to the list of immunosuppressant drugs linked to skin ulceration.
  • Clinicians should monitor for skin adverse effects in patients treated with leflunomide.
  • Further research is needed to confirm the causal relationship between leflunomide and skin ulceration.