Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mitochondria: regulating the inevitable.

P A Parone1, D James, J C Martinou

  • 1Departement de Biologie Cellulaire, University of Geneva, 30, quai E.-Ansermet, 1211 Geneva 4, Switzerland. Philippe.Parone@cellbio.unige.ch

Biochimie
|May 23, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Photosynthetic machinery under salinity stress: Trepidations and adaptive mechanisms.

Photosynthetica·2024
Same author

Early viscoelastometric guided fibrinogen replacement combined with escalation of clinical care reduces progression in postpartum haemorrhage: a comparison of outcomes from two prospective observational studies.

International journal of obstetric anesthesia·2024
Same author

Organisational challenges to wellbeing in nuclear medicine technologists: Professionalism, burnout and pragmatic growth.

Radiography (London, England : 1995)·2024
Same author

Development, implementation and evaluation of the digital transformation of renal services in Wales: the journey from local to national.

International journal of clinical pharmacy·2022
Same author

Novel TRPV4 Pathogenic Variant in Severe Metatropic Skeletal Dysplasia: A Case Report.

Malaysian orthopaedic journal·2022
Same author

A reassessment of TBT action levels for determining the fate of dredged sediments in the United Kingdom.

Marine pollution bulletin·2022

Programmed cell death, or apoptosis, is crucial for development and health. This review explores the central role of mitochondria in regulating apoptosis and its associated molecular mechanisms.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Apoptosis, a fundamental biological process, is vital for multicellular organism development and tissue homeostasis.
  • Dysregulation of programmed cell death is implicated in diseases such as cancer and neurodegenerative disorders.
  • Cell death signaling pathways are tightly controlled, originating from intracellular or cell-surface triggers.

Purpose of the Study:

  • To provide a comprehensive overview of the critical role mitochondria play in apoptosis.
  • To elucidate the molecular mechanisms by which mitochondria regulate programmed cell death.

Main Methods:

  • Literature review focusing on recent advancements in apoptosis research.
  • Analysis of signaling pathways involving mitochondria in cell death.

Related Experiment Videos

  • Examination of the release of apoptogenic proteins from mitochondria.

    • Main Results:

    • Mitochondria are now recognized as central regulators of apoptotic signaling pathways.
    • The release of specific apoptogenic proteins from mitochondria is a key event in initiating apoptosis.
    • Multiple signaling pathways converge on mitochondrial function to control cell fate.

    Conclusions:

    • Mitochondria are pivotal in the execution of apoptosis.
    • Understanding mitochondrial roles in apoptosis is essential for comprehending disease pathogenesis.
    • Targeting mitochondrial pathways offers potential therapeutic strategies for diseases involving cell death abnormalities.