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Association study of the 5-hydroxytryptamine(6) receptor gene in Alzheimer's disease
Antonio Orlacchio1, Toshitaka Kawarai, Eleonora Paciotti
1Laboratorio di Neurogenetica, I.R.C.C.S. Santa Lucia, Via Ardeatina 354, 00179, Rome, Italy. a.orlacchio@hsantalucia.it
Abstract:
Serotonergic (5-hydroxytryptamine; 5-HT) transmission has been implicated in the pathogenesis of Alzheimer's disease (AD). A coding single nucleotide polymorphism 267 (C/T) in the 5-HT(6) receptor gene was previously reported as a susceptibility factor for AD. An extensive replication study was performed using our data set including sporadic and familial cases. No significant association between the 5-HT(6) receptor gene and AD was obtained with or without the stratification of apolipoprotein E epsilon 4 status. Our result suggests that the 267C allele of the 5-HT(6) receptor gene may not be a genetic risk factor for AD.