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Related Experiment Videos

Gene expression in skeletal muscle.

G Goldspink1

  • 1Departments of Anatomy and Surgery, Royal Free and University College Medical School, Royal Free Campus, University of London, Rowland Hill Street, London NW3 2PF, U.K. goldspink@rcf.ucl.ac.uk

Biochemical Society Transactions
|May 25, 2002
PubMed
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Muscle adapts its mass and function through gene expression changes. A specific form, mechano growth factor (MGF), is activated by mechanical stress and may act as a local repair factor.

Area of Science:

  • Muscle physiology
  • Molecular biology
  • Biochemistry

Background:

  • Muscle mass and phenotype are adaptable to physical activity.
  • Gene expression, including myosin heavy chain and metabolic genes, changes with activity, affecting muscle function.
  • Muscle mass regulation involves both local and systemic factors.

Purpose of the Study:

  • To clone cDNAs for local and systemic isoforms of insulin-like growth factor-I (IGF-I) from exercised muscle.
  • To investigate the role of mechano growth factor (MGF) in muscle adaptation.

Main Methods:

  • Cloning of IGF-I isoform cDNAs from exercised muscle.
  • Analysis of gene expression changes in response to activity and injury.

Main Results:

Related Experiment Videos

  • Identified and cloned cDNAs for local and systemic IGF-I isoforms.
  • Discovered a specific IGF-I isoform, MGF, whose RNA transcript is upregulated following mechanical activity or injury.
  • MGF exhibits distinct 3' sequence and function compared to systemic IGF-I due to a reading-frame shift.

Conclusions:

  • Mechano growth factor (MGF) is an IGF-I isoform specifically expressed in response to mechanical stimuli.
  • MGF may function primarily as a local repair factor in muscle rather than a systemic growth factor.