Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Atherothrombosis: plaque instability and thrombogenesis.

Frederick L Ruberg1, Jane A Leopold, Joseph Loscalzo

  • 1Evans Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118-2526, USA.

Progress in Cardiovascular Diseases
|May 25, 2002
PubMed
Summary

Acute coronary syndrome (ACS) arises from unstable plaques that promote thrombosis. Interventions target thrombus formation and endothelial dysfunction to treat ACS.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantitative single photon emission computed tomography/computed tomography of Tc-99m-pyrophosphate scans: metrics for short-term risk stratification in transthyretin cardiac amyloidosis.

Nuclear medicine communications·2026
Same author

Metabolomic Network Analysis Reveals Reorganization of Lipid and Steroid Programs Linked to Right Ventricular-Pulmonary Vascular Function in Pulmonary Hypertension.

bioRxiv : the preprint server for biology·2026
Same author

Improved Performance of Transthyretin Cardiac Amyloidosis Score by Addition of High-Sensitivity Troponin I: The SCAN-MP Study.

JACC. Heart failure·2026
Same author

Resolving Diagnostic Discordance in Group 2 Pulmonary Hypertension Through Staged Physiologic Testing: Insights From PVDOMICS.

medRxiv : the preprint server for health sciences·2026
Same author

Phenotypic Characterization of Unclassified Pulmonary Hypertension.

Circulation. Heart failure·2026
Same author

Diagnostic Performance of the Mayo ATTR-CM Score in Diverse Populations: Comparison With the AMY Score.

JACC. Advances·2026

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Pathophysiology

Background:

  • Hemostasis relies on a balance of prothrombotic and antithrombotic factors.
  • Endothelial cell dysfunction contributes to atherosclerotic plaque development and instability.
  • Unstable plaques create a prothrombotic environment, leading to acute coronary syndromes (ACS).

Purpose of the Study:

  • To elucidate the mechanisms underlying plaque instability and thrombosis in ACS.
  • To highlight the role of endothelial dysfunction in ACS pathogenesis.
  • To inform pharmacological strategies for ACS treatment.

Main Methods:

  • Review of hemostasis and thrombosis literature.
  • Analysis of cellular and molecular interactions in plaque destabilization.

Related Experiment Videos

  • Examination of factors influencing thrombus formation and lysis.

    • Main Results:

    • Plaque instability involves interactions between immune cells, endothelial cells, and smooth muscle cells.
    • Fibrous cap degradation and altered factor expression precede thrombus formation.
    • Endothelial dysfunction is central to both lesion development and destabilization.

    Conclusions:

    • ACS is driven by vulnerable plaques favoring thrombosis due to endothelial dysfunction.
    • Pharmacological treatments for ACS aim to inhibit thrombosis and improve endothelial function.