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Initial study in rats evaluating the effects of 1,4-dichlorobutene-2 (DCB) on the respiratory tract
L S Mullin1, T Chiu, G L Kennedy
1E.I. du Pont de Nemours and Company, Haskell Laboratory for Health and Environmental Sciences, P.O. Box 50, Newark, DE 19714-0050, USA.
Abstract:
Rats were exposed by inhalation to either 0.5 ppm 1,4-dichlorobutene-2 (DCB) for two years or to 5.0 ppm for seven months, 2.5 ppm for five months, and no further exposure for 12 months prior to sacrifice. Malignant and non-malignant tumors of the nasal tissues were seen in both test groups with the incidence and proportion of malignant tumors being much higher in the 5.0/2.5 ppm rats. Under the conditions of this study, DCB is carcinogenic in rats of both sexes.
