Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Paraventricular-subparaventricular hypothalamic lesions selectively affect circadian function.

Robert Y Moore1, Rebecca L Danchenko

  • 1Department of Neurology, University of Pittsburgh, PA 15213, USA. rym@pitt.edu

Chronobiology International
|May 25, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predictive models of postural control based on electronic force platform measures in patients with Parkinson's disease.

International journal of applied mathematics·2017
Same author

Calretinin Neurons in the Rat Suprachiasmatic Nucleus.

Journal of biological rhythms·2016
Same author

The suprachiasmatic nucleus and the circadian timing system.

Progress in molecular biology and translational science·2013
Same author

Innervation of ventricular and periventricular brain compartments.

Brain research·2012
Same author

In vivo assessment of brain monoamine systems in parkin gene carriers: a PET study.

Experimental neurology·2010
Same author

The suprachiasmatic nucleus and sleep-wake regulation.

Postgraduate medicine·2009
Same journal

Effects of stocking density on growth, accelerometer-derived locomotor activity and circadian rhythms in lambs during suckling and fattening.

Chronobiology international·2026
Same journal

Multivariate associations between sleep patterns and self-regulation in adolescence: Canonical correlation analysis across ABCD and NCANDA cohorts.

Chronobiology international·2026
Same journal

Circadian amplitude and CLOCK 3111 polymorphism predict morning leptin in Arctic residents, independent of photoperiod.

Chronobiology international·2026
Same journal

A machine learning-based analysis of chronotype and sleep quality as predictors of mental distress in university students.

Chronobiology international·2026
Same journal

Maternal depressive symptoms are not linked to infant rest-activity patterns at six months.

Chronobiology international·2026
Same journal

Circadian and metabolic effects of light-phase time-restricted feeding with a Western-style diet in young female rats.

Chronobiology international·2026
See all related articles

The suprachiasmatic nucleus (SCN) controls circadian rhythms via distinct projections. Dorsal SCN pathways regulate melatonin, rostral pathways control body temperature, and caudal pathways manage rest-activity cycles.

Area of Science:

  • Neuroscience
  • Chronobiology
  • Physiology

Background:

  • The circadian timing system relies on entrainment, pacemakers, and efferent pathways.
  • The suprachiasmatic nucleus (SCN) is the main mammalian circadian pacemaker.
  • Understanding SCN efferent pathways controlling effector systems remains incomplete.

Purpose of the Study:

  • To investigate the functional organization of SCN projections.
  • To determine if specific SCN projection subsets control distinct effector systems.
  • To analyze the impact of paraventricular hypothalamic nucleus (PVH) lesions on circadian rhythms.

Main Methods:

  • Lesions were made in the PVH, with extensions into the subparaventricular zone (SPVZ).
  • Effects on nocturnal pineal melatonin, core body temperature (Tb), and rest-activity (R-A) rhythms were assessed.

Related Experiment Videos

  • Correlation between lesion extent and disruption of specific circadian rhythms was analyzed.

    • Main Results:

    • PVH ablation eliminated nocturnal melatonin production.
    • PVH lesions alone did not affect Tb or R-A rhythms.
    • Lesions extending into SPVZ disrupted R-A rhythms, linked to caudal SCN projection interruption, without affecting Tb rhythms.

    Conclusions:

    • SCN pacemaker regulation involves discrete projection sets.
    • Dorsal SCN projections to PVH control pineal melatonin.
    • Rostral SCN projections mediate Tb rhythms, while caudal projections control R-A rhythms via SPVZ and hypothalamic arousal systems.