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Updated: Aug 10, 2026

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase (G6PI)-Induced RA Mice
Published on: January 31, 2020
Thermal inactivation and gradient studies of the active agent in rheumatoid arthritis
Abstract:
Ten day embryonated eggs have been used for testing supernatants of pooled RA synovial tissues for the presence of the RA-active agent. A high thermal resistance of the agent was observed up to 40 min of heating both at 100 and 121 degrees C with complete loss of infectivity only after 60 min at 121 degrees C. The high thermal resistance at 121 degrees C suggested that the active agent does not depend on a double-stranded DNA or RNA. It probably has no protein component and has a minimal number of subunits for replication. The CsC1 ultracentrifugation identified a concentration of high infectivity at densities in the range of 1.440-1.490 g/ml in five experiments.
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