Rapid eye movement sleep behavior disorder in children with autism

Shanti S Thirumalai1, Richard A Shubin, Ricki Robinson

  • 1Department of Neurology, Children's Hospital, Los Angeles, CA 90027, USA. sthirumalai@chla.usc.edu

Insights

Five children with autism were diagnosed with REM sleep behavior disorder, a condition usually seen in older men. This finding may change how we understand autism and its treatments.

Area of Science:

  • Neurology
  • Sleep Medicine
  • Developmental Pediatrics

Background:

  • Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition.
  • Sleep disturbances, including nocturnal awakenings, are common in children with autism.
  • Rapid Eye Movement (REM) sleep behavior disorder (RBD) is typically associated with neurodegenerative diseases in elderly males.

Observation:

  • Nocturnal polysomnography was conducted on 11 children diagnosed with autism and exhibiting sleep disruption.
  • The study aimed to investigate potential underlying sleep disorders contributing to symptoms in autistic children.

Findings:

  • Rapid Eye Movement (REM) sleep behavior disorder (RBD) was identified in 5 out of the 11 autistic children studied.
  • This represents a significant prevalence of RBD in this pediatric autism cohort.
  • The presence of RBD in children with autism was unexpected given its typical demographic association.

Implications:

  • The identification of RBD in autistic children suggests potential shared neurochemical or neurophysiologic pathways between autism and RBD.
  • This finding could significantly advance the understanding of the underlying mechanisms of autism spectrum disorder.
  • Accurate diagnosis of RBD in autistic children allows for targeted treatment with medications like clonazepam, improving sleep consolidation and daytime functioning.

Related Concept Videos

REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...