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Related Experiment Videos

Functional lateralization of the human premotor cortex during sequential movements.

Petr Hlustík1, Ana Solodkin, Rao P Gullapalli

  • 1Department of Neurology, University of Maryland, Baltimore, Maryland 21201, USA. phlustik@uchicago.edu

Brain and Cognition
|May 25, 2002
PubMed
Summary

The left dorsal premotor cortex is crucial for sequential movements in both hands, challenging the idea that brain sides only control opposite body sides. This finding explains why left hemisphere damage can affect both sides of the body.

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Area of Science:

  • Neuroscience
  • Motor Control
  • Brain Imaging

Background:

  • Traditionally, it's believed each brain hemisphere controls the opposite body side.
  • However, left hemisphere lesions can cause bilateral motor impairments and ideomotor apraxia.
  • The precise role of specific brain regions in bilateral motor control remains incompletely understood.

Purpose of the Study:

  • To investigate the role of the left dorsal premotor cortex in sequential motor control for both hands.
  • To examine hemispheric activation patterns during sequential finger movements in right-handed individuals.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to monitor brain activity.
  • Participants performed sequential finger movements while in the fMRI scanner.

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  • Analysis focused on activation in the motor cortices, particularly the dorsal premotor cortex.

    • Main Results:

    • The left dorsal premotor cortex showed significant activation during sequential movements of both the right and left hands.
    • A left hemispheric predominance in activated dorsal premotor cortex volume was observed in right-handed subjects.
    • This suggests a fundamental role for the left premotor cortex in controlling sequential movements of both limbs.

    Conclusions:

    • The left dorsal premotor cortex plays a critical role in the sequential motor control of both hands, not just the contralateral hand.
    • This left-hemisphere dominance in the dorsal premotor cortex may explain bilateral motor deficits observed after left hemisphere lesions.
    • Findings challenge simple contralateral control models and highlight the complex lateralization of motor functions.