Keloids - the sebum hypothesis revisited
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Updated: Oct 1, 2026

A Rat Model of Compound Acne
Published on: November 1, 2024
1Department of Surgery, University of Malaya Medical Centre, West Malaysia. eileen@medicine.med.um.edu
Abstract:
The aetiology of the keloid scar has not been completely elucidated. Numerous hypotheses have been proposed in the past to explain the unusual characteristics of the keloid scar. While we do know that there is excessive and ongoing collagen-deposition, the exact triggering stimulus is a subject of conjecture. We present some of our photographic records of keloids and electron microscopic findings of keloid edges and reiterate the sebum hypothesis. We also attempt to explain the features of keloids in the light of the present knowledge of immunology and cell biology.
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