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Related Experiment Videos

Practical approaches to migraine management.

Seymour Diamond1, Richard Wenzel

  • 1Diamond Inpatient Headache Unit, Diamond Headache Clinic, St. Joseph Hospital, and Finch University of Health Sciences/The Chicago Medical School, North Chicago, Chicago, Illinois 60614, USA.

CNS Drugs
|May 25, 2002
PubMed
Summary

Migraine, a complex neurological disorder, is often undertreated despite available therapies. This review highlights cervico-trigemino-vascular dysfunction as a key cause and discusses effective treatments like triptans for severe attacks.

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Effect of Galcanezumab on Total Pain Burden in Patients Who Had Previously Not Benefited from Migraine Preventive Medication (CONQUER Trial): A Post Hoc Analysis.

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Area of Science:

  • Neurology
  • Clinical Medicine

Background:

  • Migraine is a complex neurological syndrome with diverse manifestations.
  • Cervico-trigemino-vascular dysfunction is implicated as a primary cause of migraine.
  • Despite advances, migraine remains under-diagnosed and poorly treated.

Purpose of the Study:

  • To review the pathophysiology of migraine.
  • To discuss current and emerging treatment options for migraine.
  • To emphasize the importance of evidence-based guidelines in migraine management.

Main Methods:

  • Literature review of pathophysiological mechanisms.
  • Analysis of clinical studies on migraine treatments.
  • Synthesis of evidence-based guidelines for migraine therapy.

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Main Results:

  • Serotonin 5-HT(1B/1D) agonists (triptans) and dihydroergotamine mesylate are recommended for moderate to severe attacks.
  • Other treatment options include ergotamine derivatives, phenothiazines, NSAIDs, and opioids.
  • Preventative therapy is crucial for frequent or refractory migraine attacks.

Conclusions:

  • Migraine pathophysiology involves cervico-trigemino-vascular dysfunction.
  • Migraine-specific drugs are effective for acute, moderate to severe attacks.
  • Improved diagnosis and adherence to guidelines are essential for better migraine management.